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Glutamine is needed to produce the neurotransmitter called glutamate

Since fecal SCFAs were not quantified and other butyrate-producing taxa (e.g., Bacteroides , Clostridium ) were not systematically evaluated, this remains a limitation that warrants future investigation

2.2 Inclusion and exclusion criteria 2.2.1 Inclusion criteria Subjects/Disease: Rheumatoid arthritis (RA), including both clinical studies (RA patients) and animal model studies (e.g., collagen-induced arthritis [CIA] and adjuvant-induced arthritis [AIA])

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First of all, the study population was mainly from Iran, and the number of participants was small, so it needs to be further verified by increasing the sample size in future studies