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In summary, while systemic IV DFO is invasive and non-specific for brain delivery for chronic brain iron overload, it may have potential applications for immediate effect and is useful in acute neurological damage where iron is rapidly released and accessible (e.g., acute iron poisoning or ICH)

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Based on the point system, average delay to diagnosis was 833 days for two points (n=20, 12.3%), 1366 days for 3 points (n=99, 55.2%), 472 days for 4 points (n=39, 23.9%) and 106 days for 5 points (n=13, 8%)

J Ethnopharmacol 308:116267 Wu Y, Wang F, Fan L, Zhang W, Wang T, Du Y, Bai X (2018) Baicalin alleviates atherosclerosis by relieving oxidative stress and inflammatory responses via inactivating the nf-kappab and p38 mapk signaling pathways