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Further mechanistic studies in TgSwDI mice indicate that OC also activates the ApoE-dependent amyloid clearance pathway and increases A-degrading enzymes, allowing a multifaceted reduction in cerebral amyloid burden (80)

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Betaine supplementation modulates betaine concentration by methylenetetrahydrofolate reductase genotype, but has no effect on amino acid profile in healthy active males: A randomized placebo-controlled cross-over study