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Genetic variants in the MUT gene, causing MMA, can be divided into two types: (Mut-), a partial genetic variant in the MUT gene that results in low to moderate residual MUT activity in the presence of high concentrations of Adenosylcobalamin (AdoCbl), and (Mut0), a complete genetic variant in the MUT gene resulting in virtually undetectable MUT activity [12]

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For example, ionotropic glutamate receptors represent ligand-gated calcium channels while GABA receptors trigger calcium influx via voltage-gated calcium channels [94]

doi: 10.1111/cen.14359