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X-ray crystallographic studies have demonstrated that copper coordination occurs through the N-terminal amino group of glycine, the deprotonated peptide nitrogen of the Gly-His bond, and the imidazole nitrogen of histidine, forming a square-planar geometry characteristic of Cu(II) complexes

Zingariello, P

It is a vital cofactor of numerous important enzymes, such as dopamine monooxygenase, cytochrome oxidase, and the free radical scavenger superoxide dismutase (Uauy et al., 1998

Although FDA does not currently clear or approve laboratory-developed tests in the U.S., certification of the laboratory is required under CLIA to ensure the quality and validity of the tests

& Qureshi, M