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Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors

The oncometabolite 2-hydroxyglutarate produced by mutant IDH1 sensitizes cells to ferroptosis

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These reactions are catalyzed by lysine acetyltransferase (KAT), and the reverse process is regulated by lysine deacetylase (KDAC), while the acetyl group can add to the amino acid at the N-terminus via N-terminal acetyltransferases (NATs) 114,115

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