l-carnitine crohn's disease The intestinal microbial metabolite acetyl improves gut inflammation and immune homeostasis via CADM2 Role of L-carnitine in Cardiovascular

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The inflammatory factors like IL-6, IL-1 and TNF- that initiate inflammation response are mostly secreted by M1 type macrophages, and they influence the activity of enzymes in iron, lipid and amino acid metabolisms [40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57]

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GPER activation also modulates intracellular calcium dynamics, triggering rapid calcium release, which may be crucial for the function and survival of various bone components [131]