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Activated TGF- binds TGF- Receptor Type II (TRII), which recruits and phosphorylates TGF- Receptor Type I (TRI), leading to phosphorylation of Smad2/3 and inhibition of Smad7

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*Correspondence: Alfredo Gimnez-Cassina [email protected] Present address: Daro Garca-Rodrguez, Instituto de Biologa Funcional y Genmica (IBFG USAL-CSIC), Universidad de Salamanca, Salamanca, Spain Specialty section : This article was submitted to Molecular Signalling and Pathways, a section of the journal Frontiers in Molecular Neuroscience Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Under hypoxia, the activity of the prolyl hydroxylases is inhibited, due to both lower oxygen availability and ROS generation by the mitochondria