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A deficiency in either of these nutrients can lead to megaloblastic anemia, a condition in which red blood cells become abnormally large and do not function properly

found that mutations in the PNPO genes R225H/C, D33V, and R116Q/P significantly reduced PNPO activity and increased the likelihood of PN-responsive epilepsy [35]

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A 2018 study published in Biochemical Pharmacology showed that inhibiting NNMT with 5-Amino-1MQ led to a reduction in fat mass in mice on high-fat diets