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For example, in AD research, an FRG signature composed of genes such as DNA damage inducible transcript 4, mucin 1 and CD44 was found to not only distinguish patients with AD from healthy controls but also to predict disease severity and immune cell infiltration in the brain (43)

While we summarised the technical challenges, there are many organisational challenges to be addressed to deploy an AI-based coding tool into the clinical coding environment, as reviewed in Campbell and Giadresco 9 , where an essential idea is that coders need to be involved in the model development and deployment stage