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Nucleophosmin-1 (NPM1) gene mutation occurs in about 5060% of AML patients with normal karyotype [51]

Keap1-Nrf2 Pathway and Autophagy The selective autophagy substrate p62 contains an ETGE-like motif, STGE, which could be phosphorylated by mTOR complex 1 to bind to Keap1 with higher affinity (Taguchi et al., 2012)