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Interestingly, enhanced protein stability at low pH as a strategy to avoid acid induced unfolding has also been observed in many proteins including cytokines, interleukin-2 (IL-2) and granulocyte colony stimulating factor (G-CSF), which usually get internalised in acidic endosomal compartments, and capsid proteins which ensure viruss survival in acidic intestinal tract 18,19,20

As protein abundance of Gpx3 in BALF under normal conditions was substantially higher than for Gpx1 (Fig