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High prevalence of B 12 deficiency has frequently been reported in subjects undergoing bariatric surgery (Sumner et al., 1996

By inhibiting NNMT, the compound shifts cellular metabolism away from fat storage and toward fat burning

Several plant-derived substances, such as celastrol (20) and withaferin (21) have been tested in diet-induced obese rodents for improvement of this pathway that leads to leptin resistance