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In DFU, notch pathway dysfunction can lead to inhibition of cell differentiation, proliferation disorders, and reduced angiogenesis, all of which interfere with diabetic wound healing

Remarkably, the inhibitory effect of NO was associated with S -nitrosylation of GSNOR1 both in vitro and in vivo (Fig

doi: 10.7150/ijbs.86911 [DOI] [PMC free article] [PubMed] [Google Scholar] 7.Kumar AB, Shamim H, Nagaraju U

Aerts S A scalable SCENIC workflow for single-cell gene regulatory network analysis

Indeed, CiiiDER analysis (Gearing et al., 2019) revealed that there are predicted promoter-binding sequences that distinguish the 61 shared target genes from the top 200 ATF4-dependent genes induced by the ISR alone (Figure 2A supplementary table 2)