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In general, by either excess or impairment, NO appears to cause or contribute to a variety of disturbances, in particular, hypertension, angina, impotence, circulatory shock, septic shock, stroke, inflammation, respiratory distress syndromes, pulmonary hypertension, adhesion and aggregation of platelets and leukocytes, diabetes, hypotension, and Parkinson's disease

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They can also be used as part of injury prevention strategies in high-performance populations and for the management of age-related conditions, such as sarcopenia, osteoarthritis, or persistent tendinopathies

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As such, it can be used either for binary classification or ordinal classification with three levels