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Other factors Beyond the VEGF/VEGFR , EGF/EGFR , and PDGF/PDGFR axes, many other growth factors play indispensable roles in angiogenesis, such as fibroblast growth factor ( FGF ) /FGFR4 , hepatocyte growth factor ( HGF ) /c-Met , insulin-like growth factor ( IGF ) /IGFR , and transforming growth factor ( TGF- ) ( Figure 1 )