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What it does not establish is that this process is ever visible to the naked eye as a temporary worsening in normal, healthy skin outside a wound-healing context, or that it happens in a way tied to dose or frequency of use

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A REGISTRY-BASED CASE-CONTROL STUDY Guri Hagberg 1,2 , Hkon Ihle-Hansen 3,4 , Tamar Abzhandadze 2,5 , Malin Reinholdsson 2,5 , Adam Viktorisson 2,6 , Henri Pesonen 7 , Hege Ihle-Hansen 4 , Katharina Stibrant Sunnerhagen 2,6 1 Oslo Stroke Unit, Department of Neurology, Oslo University Hospital, Oslo, Norway, 2 Institute of Neuroscience and Physiology, Section for Clinical Neuroscience and Rehabilitation, Gothenburg University, Gothenburg, Sweden, 3 Department of Medicine, Brum Hospital- Vestre Viken Hospital Trust, Drammen, Norway, 4 Research department Brum Hospital, Vestre Viken Hospital Trust, Drammen, Norway, 5 Department of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital, Gothenborg, Sweden, 6 Neurocare, Sahlgrenska University Hospital, Gothenburg, Sweden, 7 Oslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, Norway Background and Aims: Patient reported outcome measures (PROMs) could expose meaningful differences but are scarcely investigated in acute stroke trials