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M., Magarkar, A., Kfinger, J., Hummer, G

A cycloheximide (CHX) chase experiment showed that co-treatment rescued the FOXO3a protein level and resulted in a steady level of FOXO3a protein (Fig

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- Contributes to the promotion of gut health

BH4 is a strong antioxidant that sequesters radicals and, either by itself or in combination with vitamin E, prevents lipid membranes from undergoing autoxidation (189).The transsulfuration pathway, mevalonate pathway, ferroptosis inhibitory protein 1 (FSP1)-coenzyme Q10 (CoQ10) pathway, dihydroorotate dehydrogenase (DHODH)-dihydroubiquione (CoQH2) pathway, and GTP cyclohydrolase-1 (GCH1)-tetrahydrobiopterin (BH4) pathway are among the other antioxidant systems that have also been linked to the regulation of ferroptosis (190) ( Figure 5 )