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Angiogenesis, the formation of new blood vessels, is essential for tumor growth and metastasis [113]

Sinclair DA

The natural sesquiterpene lactone compound Alantolactone, extracted from the roots of Inula helenium, specifically inhibited the activity of Lin-11, Isl-1, and Mec-3 kinase (LIMK), inducing the dephosphorylation and activation of its key substrate, cofilin