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Moreover, unlike biologics that typically require parenteral delivery, SM can be developed into oral dosage forms, boosting patient satisfaction and compliance (Olivera et al., 2017)

Trends Endocrinol Metab (2019) 30:35768

Important gaps persist, including limited long-term safety data in vulnerable populations, incomplete monitoring of antimicrobial resistance transfer, and scarce head-to-head comparisons between strains or formulations, which hinder the development of clear, strain-specific clinical guidelines (3, 17)

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Using sunscreen over the routine in the morning is important, as UV exposure actively worsens pigmentation and works against the brightening actives