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With the deepening research on the pathogenesis of PCOS and its chronic inflammatory state, it has been found that a variety of signaling pathways are involved in the initiation and progression of inflammation (222), among which the more important ones such as PI3K/AKT, MAPK, and AMPK signaling pathways, and the SCFAs have anti-inflammatory roles in PCOS, but these signaling pathways have been reported less frequently in the study of SCFAs

In contrast, inhibition of LDH activity may only abolish l-lactate production but not affect the glyoxalase pathway (Fig

The combined organic layer is then successively washed with water (10 Vol) and brine solution, dried over sodium sulphate, filtered and concentrated under reduced pressure to get the desired compound