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Sometimes its because you start to eliminate too fast the toxins and all that, but sometimes it can be life threatening, because of that

10.1080/15384101.2019.1648957 56 LesickaM.JaboskaE.WieczorekE.SeroczyskaB.KalinowskiL.SkokowskiJ.et al (2019)

Bi-allelic mutations in phe-tRNA synthetase associated with a multi-system pulmonary disease support non-translational function

Environmental factors such as pollution, ultraviolet radiation, and exposure to mutagenic and carcinogenic agents can damage body cells by generating reactive oxygen species (ROS), which leads to oxidative stress

One such mechanism is the possibility for autophagy to engage with various cytokines, like IL-6, influencing the activation of CSC survival pathways, including STAT3