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N- formylmethionine (fMet), a metabolite in one-carbon metabolism, was identified as one of the most elevated metabolites with 145% change (p = 0.04) ( Figure 7B & 9 ), but no other metabolites present in the metabolomics profiling directly linked to the one-carbon pathway were found to be dysregulated

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doi: 10.1002/ijc.26062 121 ZhangJSattlerMTononGGrabherCLababidiSZimmerhacklAet al

In the anterior cingulate cortex, female MDD subjects showed reduced KYNA and lower KYNA/QA ratios compared to female controls, and those who died by suicide had lower KYNA compared to non-suicidal MDD subjects [65]