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And that is not observed: Children with IGF1 defects suffer from far more severe fetal growth retardation with birth weight SDS around -4 and birth length SDS of -5 to -6 (reviewed in (58)

However, resistance and relapse in patients have sparked interest in novel approaches using sdAbs derived from camelid species, which have favorable properties that can potentially overcome the limitations of traditional monoclonal antibodies

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For more information on the forms, see Coenzyme Forms: Methylcobalamin and Adenosylcobalamin