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Furthermore, a synergistic effect between smoking and alcohol consumption on elevated ALT levels has been observed in HCV patients, indicating that the combined exposure significantly exacerbates liver injury [84]

In addition, in an HHcy-induced 2-kidney, 1-clip (2K1C) hypertensive murine model and Hcy-B CM-treated glomerular endothelial cells (GECs), a significant increase in the ferropotosis rate was triggered through iron accumulation, lipid peroxidation, upregulation of TFR1, and downregulation of SLC7A11 and GPX4 [262]

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[DOI] [PubMed] [Google Scholar] 43.Liu Q, Li S, Quan H, Li J

If its from inadequate protein or B-vitamin deficiency, supplementation may help