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3 Mechanisms of mitochondrial energy metabolic reprogramming 3.1 Transition of energy metabolism pathways Under physiological conditions, TECs actively absorb circulating FAs through specific transporter proteins, including CD36 and FA-binding proteins

Shklar and coworkers (173) examined the effects of methotrexate on hamster buccal pouch carcinomas generated by 9,10-dimethyl-l,2-benzanthracene and found that the methotrexate-treated group reported tumors that were larger and more anaplastic and that they progressed more quickly than the control group

2017;8(10): e3081

A vitamin B-12 supplement of 500 g/d for eight weeks does not normalize urinary methylmalonic acid or other biomarkers of vitamin B-12 status in elderly people with moderately poor vitamin B-12 status

NAC uniquely impacted pathways such as gluconeogenesis, mitochondrial electron transport chain, branched-chain fatty acid oxidation, phytanic acid peroxisomal oxidation, and glycine-serine metabolism