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Although these effects are less pronounced than those seen with ATRA, STAT3 inhibitors or STAT1 activators are being explored as promising candidates for combination therapies with Daratumumab ( 2.1.1.4 Degradation of CD38 mRNA Research involving microRNA (miR) has demonstrated that noncoding RNA can influence CD38 expression, with miR-26a and miR-140-3p being key candidates for investigation