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Our MD results demonstrated the ability of both n-hexadecanoic acid and L-car to form hydrogen bonds with the ASN226 residue of SIRT1, indication their ability to activate SIRT1 74

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5 Natural flavonoids as ferroptosis inhibitors for the therapy of CNS diseases Flavonoids are one of the largest classes of plant polyphenols, characterized by a C6-C3-C6 backbone consisting of three rings labeled as A, B, and C (Dias et al., 2021)

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In a study involving SAH model rats, oral administration of CU (10 mg/kg) over the course of 1 week resulted in a significant reduction in glutamate and GLT-1 expression, with malondialdehyde (MDA) levels in the hippocampus and cortical regions decreasing by 18% and 29%, respectively