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MARCH was a 26-week, randomized, placebo-controlled (PBO), Phase 3 trial of maralixibat (MRX), an ileal bile acid transporter (IBAT) inhibitor, that achieved its primary and key secondary endpoints of pruritus and sBA reduction for individuals across the broadest range of PFIC types studied

Kulasekaran, P

Targeted deletion of the gene coding for Trsp results in early embryonic lethality at the egg cylinder stage (gestational day E6.0) which highlights the importance of selenoproteins for embryonic survival (Bosl et al., 1997)