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Proteomic support is provided by ex vivo studies of human PACs demonstrating that human acini preserve key physiological properties while developing pancreatitis-relevant stress responses and organellar abnormalities, indicating that several mechanistic features identified in rodents are also detectable in human acinar tissue (96)

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doi:10.1016/j.neubiorev.2018.05.005

It is a reasonable step up for normal-to-resilient skin, but the incremental benefit over 1% is not dramatic and depends heavily on the quality of the surrounding formula