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doi: 10.1002/jcb.2218 127 MarksP

Redness over an involved joint (gout is highly inflammatory) Involvement of the base of the big toe on one side (the most common site for gout) Involvement of the joints at the middle of the foot Uric acid elevation on blood testing X-ray findings of swelling of joints which is not symmetrical Joint fluid is tested for infection and is negative

Potential neuroprotective effects Early studies suggest a role in supporting nerve healing and cognitive health

How to prevent Injection Site Redness The risk of infusion site redness can be lowered by taking a histamine blocker such as diphenhydramine (Benadryl), cetirizine (Zyrtec), or loratadine (Claritin) 1-3 hours before the injection