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Our findings provide a structural framework to understand how COP1 and DET1 cooperate to degrade key substrates such as c-Jun

plantarum can improve lipid oxidation by increasing the mRNA expression of lipid oxidation genes, including CPT1, ACOX1, and MCAD, and reduce lipid synthesis by activating the SIRT1-PGC-1 alpha pathway, leading to reduction of fat accumulation (Kwon et al., 2020)

Overall, these findings place NAC as a powerful co-adjuvant tool to enhance the effectiveness of MAL-PDT treatment for cSCC by preventing the development of resistance

Romanos-Nanclares et al., 2021), the repeated assessment of ASB intake at least every 4 years since the 1980s and 1990s and the analytical strategy of updating diet data during follow-up constituted major strengths and allowed potential variations in trends in ASB intake over time to be taken into account