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Interestingly, the placement of the methoxy group for 60 in each rotamer alters the position of the Ser92 side chain, where in the rotamer with the methoxy pointing toward Ser92, the hydroxyl containing side-chain was directed away the ligand ( Figure 5E )

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2b, 2c), while 462 labeled metabolites and 1018 isotopologues, covering 36 metabolic pathways, were identified using the U- 13 C glutamine tracer (Fig