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Upon activation, HSF1 trimers translocate to the nucleus and bind to heat shock elements (HSEs) in the promoters of target genes, thereby increasing the transcription of HSP70s, which then undergo degradation or re-monomerization (Vihervaara and Sistonen, 2014)

Kim D, Whang CH, Hong J, Prayogo MC, Jung W, Lee S, Shin H, Kim Y, Yu J, Kim MJ, Kim K, Lee HS, Jon S

126 Capture: Nanoparticles achieve targeted bacterial capture through surface functionalization

Due to its critical and very pleiotropic activity, reduction of BDNF levels and alterations in the BDNF/TrkB signaling are connected with a broad spectrum of neurological diseases