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Metabolomics-based research may further reveal valuable biomarkers for therapy monitoring, as the reprogramming of ammonium metabolism in prostate cancer generates a range of intermediate metabolites, such as polyamines, citrate, and various amino acids, as well as key metabolic enzymes, which hold promise as indicators of therapeutic response (284)

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67, 68 Interestingly, MM-derived exosomes (containing TYRP2, VLA4, HSP70, MET, and Rab27a proteins) can have an impact on cells and organs both locally and at distant sites (lymph nodes, bone marrow), with a net effect of enhancing invasion and priming a metastatic niche

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