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doi: 10.1007/s12016-021-08883-0 3

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DNA damage induced by free radicals includes base modifications, strand breaks, and cross-linking

Weight loss and subsequent maintenance are reliant on energy balance

They found that in NRF-2/PGC-1 dKO mice, there is elevation of various autophagosomal markers (p62/SQSTM1, Beclin-1 and LC3B) along with the increased levels of microglia marker, Iba1 and accumulation of oxidative stress markers (4-HNE) and endoplasmic reticulum stress markers (GRP78 and ATF4