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Four main factors are involved in the development of acne: (1) abnormal follicular keratinocyte hyperproliferation, leading to the formation of a follicular plug, (2) increased sebum production within sebaceous follicles, (3) the proliferation of micro-organisms (e.g., Cutibacterium acnes (formerly Proprionibacterium acnes )) in the retained sebum, and (4) inflammation (Figure 1)

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Hepatotoxicity Related to Anti-tuberculosis Drugs: Mechanisms and Management