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Adverse effects of acetylcysteine following oral inhalation or intratracheal instillation may include stomatitis, nausea, vomiting, drowsiness, clamminess, severe rhinorrhea, and fever

Yes this is one of its advantages over oral supplementation

Rafi A, Do LT, Katz R, Sheinkopf LE, Simons CW, Klaustermeyer W (2010) Effects of omalizumab in patients with food allergy

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