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13 Another study found that patients with MDD had significantly lower plasma levels of ALC compared to healthy controls, and these levels were inversely correlated with depression severity and duration

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Although corticosteroid use in individuals with MMA is associated with risks due to catabolic effects on muscle [21], no notable corticosteroid-related adverse events were observed in this study, even with extended courses of treatment, suggesting that corticosteroids can be safely administered as needed to patients with this condition who are receiving gene editing therapy