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doi: 10.1007/s00125-019-4859-4 157 IshibashiYMatsuiTYamagishiS

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Ahmad R, Al-Roub A, Kochumon S, Akther N, Thomas R, Kumari M, Koshy MS, Tiss A, Hannun YA, Tuomilehto J, Sindhu S, Rosen ED (2018) The synergy between palmitate and TNF-alpha for CCL2 production is dependent on the TRIF/IRF3 pathway: implications for metabolic inflammation

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If left unchecked, lipid peroxidation destroys the structural integrity of the mitochondria and triggers a highly inflammatory form of programmed cell death known as ferroptosis, a mechanism heavily implicated in the pathophysiology of ME/CFS