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The 50 and 130 kDa low-molecular-weight forms specifically produced significant wrinkle-depth reduction by mean roughness (Ra) and maximum roughness (Rz) measurement, attributed to deeper dermal penetration of the smaller molecules [7]

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Moreover, this effect was conserved even in the presence of pro-apototic cytokines, suggesting that it may play a dominant role, even within the context of an active inflammation[156]

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