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S -glutathionylation can be caused via thiol-disulfide exchange with GSSG and by activation of thiols to sulfenic acid, sulfenylamides, thiyl radicals, thiosulfinate or S -nitrosyl intermediates (Gallogly and Mieyal, 2007

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Enhancing Antioxidant Defense One of the primary ways glutathione supports immune function is by enhancing antioxidant defense mechanisms

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