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GSH/GSSG Ratio Determination in Different Cell Lines Limit of Detection Using Reduced (GSH) and Oxidized (GSSG) Glutathione Protocols Complete Protocol Specifications Catalog Number: What's in the box

[DOI] [PMC free article] [PubMed] [Google Scholar] 31.Gonzlez-Domenech PJ, Daz Atienza F, Garca Pablos C, Fernndez Soto ML, Martnez-Ortega JM, Gutirrez-Rojas L

US20110065655

Further mechanistic investigations determined that the elevation of intracellular GSSG levels resulted in NF-B inhibition by facilitating glutathionylated IKK- (IKK--SSG) formation, leading to enhanced TNF hepatotoxicity

and the concentrations that are effective in vitro are often greater than those that can be achieved in vivo without delivering the product directly to the desired site of action (via a targeted delivery system)