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GonzalezRobles C, Athauda D, Barber TR, Barker RA, Dexter DT, Duty S, et al

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GHK initiates the cellular downstream pathway and exerts bioactivities through binding with cell surface receptors ( In vitro and in vivo studies proved that this combination stimulates the synthesis of collagen and glycosaminoglycans (Figure 1), respectively

In fact, HDL have many beneficial properties, including anti-inflammatory, anti-oxidative, anti-thrombotic, anti-infectious, anti-apoptotic, intercellular communication, and pro-vasodilatory capacities

Various targets (e.g., GCL, GGT, xCT, and NRF2) and compounds provide diverse avenues for modulating GSH levels, but challenges in achieving specificity and managing potential off-target effects underscore the complexity of this approach