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Since several amino acids emerged among the best discriminating metabolites in 1 H-NMR analyses, we employed a targeted UPLC/MS approach to better evaluate the serum amino acids profile of PD patients

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Senomorphics: Modulating the Senescence-Associated Secretory Phenotype (SASP) Unlike senolytic therapies that aim to directly eliminate senescent cells, senomorphics work by modulating the senescence-associated secretory phenotype (SASP), which consists of pro-inflammatory cytokines, chemokines, growth factors, and extracellular matrix-degrading enzymes secreted by senescent cells

J.CadacioC.et al (2007)

However, without simultaneous reduction of obesity, the remarkable resistance to developing steatosis in hepatocyte Cul3-deficient mice paradoxically caused profound systemic insulin resistance