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The immunochemical staining and statistical analysis indicated an upregulated REST expression level in ATN, which was positively correlated with the markers of kidney injury, Scr and BUN (Figure 1, AC)

As such, an HPLC-UV method is needed to characterize GSH drug substance and GSH impurities simultaneously

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The compound incorporates three non-standard structural features: an -aminoisobutyric acid (Aib) at the N-terminus bearing no stereocenter, a D-2-naphthylalanine (D-2-Nal) at position 3, and a D-phenylalanine at position 4

Considering the above, it appears reasonable to include substances that would not only restore normal glycemia and tissue sensitivity to insulin but also positively affect mitochondrial functions at the stage of hyperglycemia