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This widespread dietary exposure is concerning, as ACR has been linked to cytotoxicity (Kianfar et al., 2020), neuroinflammation (Yazadanpanah et al., 2023), and carcinogenicity (Koszucka et al., 2020)

This extraordinary property allows R-ALA to penetrate virtually every tissue in the body, including the lipid-rich membranes of cells and the interior aqueous cytosol

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Kri S, Szab C, Kelemen O

Interestingly, the metabolomics results showed that the synergistic effect was related to metabolic disorders, especially the substantial influence on glycerophospholipid metabolism, which significantly increased membrane permeability