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While supplementing with large doses of B12 will reduce MMA levels more than will smaller doses, there are no clear benefits (more info in Appendix A

[11] Bile-acid sequestrants and orlistat impair intestinal absorption of fat-soluble vitamins, explaining why some patients switch to parenteral therapy, whereas magnesium-containing antacids and digoxin can synergise with vitamin D to provoke hypermagnesaemia or digitalis toxicity if calcium rises unchecked

Discussion We previously reported that mutant mice harboring a single amino acid substitution in the insulin receptor ( Insr P1195L/ + mice) exhibit insulin resistance but normal glucose tolerance 6

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