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Vdac, a multi-functional mitochondrial protein regulating cell life and death

Lipid metabolism reprogramming Reprogramming of lipid metabolism is a key feature in the development of TC by coordinating the synthesis and breakdown of fatty acids to meet the energy needs and biosynthetic requirements of the tumor

Gastrointestinal (celiac disease, IBD), endocrinal (hypothyroidism, hypoparathyroidism, type 1 diabetes mellitus), hematological (autoimmune hemolytic anemia), and dermatological (early onset acne, vitiligo, and psoriasis) are among the most prevalent CEAIDs in children with AIH [4, 9, 34,35,36,37,38]

These results suggest that metformin promotes GLUT1 expression through TXNIP suppression, independently of AMPK, and probably via mitochondrial complex I inhibition

[DOI] [PMC free article] [PubMed] [Google Scholar] 132.Halasi M., Wang M., Chavan T.S., Gaponenko V., Hay N., Gartel A.L