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The amido group is used to activate the ribose backbone, using PRPP amidotransferase, the first committed step of de novo purine synthesis, as well as to produce carbamoyl phosphate in the first step of pyrimidine metabolism

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Strategies can be broadly categorized into three groups: repurposing approved drugs for immunomodulatory effects, developing new drugs against emerging metabolic targets, and modulation via dietary and microbial interventions